Description

A tremendous obstacle to curing people of HIV infection is the manner in which the virus hides in a reservoir composed primarily of dormant immune cells. By large it is believed that HIV does not reproduce in these cells for the reason that the virus relies on active cellular machinery to do so. However currently, two new papers by NIAID grantees suggest that the virus itself--not cells--controls whether HIV is replicating, and that periods of latency paradoxically give the virus a survival advantage. The discoveries could clarify as to why HIV cure strategies to awaken cells in the latent reservoir have not succeeded.

http://www.sciencedaily.com/releases/2015/02/150227112749.htm

HIV Controls its Activity Independent of Host Cells

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